carbonic acid,2-(chloromethyl)oxirane,prop-2-en-1-amine
Sevelamer carbonate
CAS: 845273-93-0
Molecular Formula: C7H14ClNO4
carbonic acid,2-(chloromethyl)oxirane,prop-2-en-1-amine - Names and Identifiers
| Name | Sevelamer carbonate |
| Synonyms | Sevelam Sevelamer carbonate 2-Propen-1-aminepolymerwith 2-Propen-1-amine polymer with (chloromethyl)oxiran carbonic acid,2-(chloromethyl)oxirane,prop-2-en-1-amine 2-Propen-1-amine polymer with (chloromethyl)oxirane carbonate Carbonic acid, compd. with 2-(chloromethyl)oxirane polymer with 2-propen-1-amine |
| CAS | 845273-93-0 |
| EINECS | 682-521-9 |
| InChI | InChI=1/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4) |
carbonic acid,2-(chloromethyl)oxirane,prop-2-en-1-amine - Physico-chemical Properties
| Molecular Formula | C7H14ClNO4 |
| Molar Mass | 211.64 |
| Appearance | Solid |
| Color | White to Pale Beige |
| Storage Condition | Room Temperature, under inert atmosphere |
| In vitro study | Sevelamer carbonate is designed to replace Sevelamer hydrochloride and has an enhanced buffering capacity. The Sevelamer moiety comprises a carbon backbone with a polyamine, each amino group being separated from the backbone by a single carbon atom. In the intestine, Sevelamer carbonate is protonated and subsequently binds to phosphorus atoms in the diet through the interaction of ions and hydrogen. The result of these interactions is a decrease in phosphorus levels in the gastrointestinal tract, leading to a decrease in both dietary phosphorus absorption and serum phosphorus levels. In addition to its effect on phosphorus levels, the polymeric amine structure of sevelamer binds to bile acids to reduce total cholesterol levels. |
| In vivo study | In an experimental model of chronic kidney disease, Sevelamer Carbonate is able to reduce inflammation and endotoxemia caused by renal failure. Sevelamer carbonate also has beneficial effects on renal dysfunction, secondary hyperparathyroidism, and vascular calcification in rats fed a high phosphorus diet. |
carbonic acid,2-(chloromethyl)oxirane,prop-2-en-1-amine - Reference Information
| hyperphosphatemia treatment drugs | tumor lysis syndrome is the rapid death of a large number of tumor cells, the release of intracellular components into the circulation, lead to including hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia and other metabolic disorders, eventually occur acute Oliguria renal failure. The most serious consequence of hyperkalemia is a fatal arrhythmia. hyperphosphatemia, a common metabolic complication of tumor lysis syndrome, reduces renal function, leading to a further reduction in urinary potassium and phosphate excretion. hypocalcemia is a consequence of hyperphosphatemia and can cause muscle spasms, arrhythmias, etc. hyperphosphatemia can be treated with phosphate binders. In addition, should as far as possible without phosphorus drugs, avoid eating high phosphorus food. Hypocalcemia can be self-adjusted by regulating blood phosphorus level. Calcium gluconate should be given when the patient has symptoms. sevelamer is a commonly used phosphate binder that delays the absorption of phosphate from the intestinal tract and combines with the phosphate in the food of the digestive tract to form insoluble calcium phosphate. Adults are recommended to start with 800-1600mg tid. Adverse reactions were Nausea Vomit, constipation, Diarrhea, etc. sevelamer hydrochloride has no systemic absorption, so it has high safety, can effectively control the blood phosphorus value and will not cause side effects such as hypercalcemia, sevelamer hydrochloride tablets (trade name Renagel) were approved by the U. S. Food and Drug Administration for production by two pharmaceutical companies, Genzyme generations and GelTex, on 30 October 1998. For the treatment of hyperphosphatemia in end-stage renal disease patients undergoing hemodialysis, the combination of sevelamer hydrochloride and calcitriol can also be used to control parathyroid hormone levels in renal failure patients. clinically, high blood phosphorus levels may lead to fatal complications in hemodialysis patients, while sevelamer hydrochloride combines and removes dietary phosphorus in the digestive tract and normal digestive processes, does not cause hypercalcemia caused by conventional therapy. |
| Use | sevelamer is a non-calcium-containing phosphate binder commonly used by kidney friends in maintenance hemodialysis, because it does not increase blood calcium level, relatively few adverse reactions, high long-term drug safety and is recommended for clinical use, can also be used for the treatment of diabetes, kidney disease. |
| side effects | common side effects of sevelamer include constipation, Abdominal Pain, abdominal distension, Nausea, Vomit, and dyspepsia. In addition, a small number of cases of pruritus, rash, ileus, and intestinal perforation have been reported in patients using sevelamer. |
| biological activity | Sevelamer Carbonate is a non-absorbable phosphate, conjugated to a cross-linked polymer, with a polymeric structure similar to sevelamer hydrochloride, only in which the carbonate is substituted for the chloride as the counterion. |
Last Update：2024-04-09 19:05:15
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